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Index > Protein center > UCP1(Gene name) > Human
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  • UCP1 (Gene name),
  • Mitochondrial brown fat uncoupling protein 1 (Protein name ),  UCP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UCP1(SLC25A7;UCP);
    Protein name:
    Mitochondrial brown fat uncoupling protein 1(UCP 1);
    Alternative:
    Thermogenin;Solute carrier family 25 member 7;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Acts as a dimer forming a proton channel.
    Function:
    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
    Subcellular Location:
    Mitochondrion inner membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    307
    Sequence:
    50:
    MGGLTASDVH | PTLGVQLFSA | GIAACLADVI | TFPLDTAKVR | LQVQGECPTS | 
    100:
    SVIRYKGVLG | TITAVVKTEG | RMKLYSGLPA | GLQRQISSAS | LRIGLYDTVQ | 
    150:
    EFLTAGKETA | PSLGSKILAG | LTTGGVAVFI | GQPTEVVKVR | LQAQSHLHGI | 
    200:
    KPRYTGTYNA | YRIIATTEGL | TGLWKGTTPN | LMRSVIINCT | ELVTYDLMKE | 
    250:
    AFVKNNILAD | DVPCHLVSAL | IAGFCATAMS | SPVDVVKTRF | INSPPGQYKS | 
    300:
    VPNCAMKVFT | NEGPTAFFKG | LVPSFLRLGS | WNVIMFVCFE | QLKRELSKSR | 
    307:
    QTMDCAT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    SMR:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human UCP 1
    Cat.:
    E2067m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human UCP 1
    Cat.:
    E2067d
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human UCP 1
    Cat.:
    E2067h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human UCP 1
    MSDS:
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    ELISA Kit for Human UCP 1
    Cat.:
    E2067b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human UCP 1
    Cat.:
    E2067r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 1
    Cat.:
    U2067r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 1
    MSDS:
    Please sign in first.
    CLIA Kit for Human UCP 1
    Cat.:
    U2067d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human UCP 1
    Cat.:
    U2067m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human UCP 1
    Cat.:
    U2067h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human UCP 1
    Cat.:
    U2067b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human UCP 1
    Cat.:
    P2067Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 1
    Cat.:
    P2067Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 1
    Polyclonal Antibody for Human UCP 1
    Polyclonal Antibody for Human UCP 1
    Cat.:
    P2067Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human UCP 1
    Monoclonal Antibody for Human UCP 1
    Monoclonal Antibody for Human UCP 1
    Monoclonal Antibody for Human UCP 1
    Monoclonal Antibody for Human UCP 1
    Monoclonal Antibody for Human UCP 1
    Monoclonal Antibody for Human UCP 1
    Protein for Human UCP 1
    Protein for Human UCP 1
    Protein for Human UCP 1
    Protein for Human UCP 1
    Protein for Human UCP 1
    Protein for Human UCP 1

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    References
    1. 1.
      "Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4."
      Cassard A.M. , Bouillaud F. , Mattei M.-G. , Hentz E. , Raimbault S. , Thomas M. , Ricquier D.
      J. Cell. Biochem.43:255-264(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      Bouillaud F.
      Submitted (1995-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Sequence of the cDNA coding for the human uncoupling protein UCP."
      Bouillaud F. , Ricquier D. , Raimbault S.
      Submitted (1995-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brown adipose tissue.
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe."
      Bouillaud F. , Villarroya F. , Hentz E. , Raimbault S. , Cassard A.M. , Ricquier D.
      Clin. Sci.75:21-27(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 113-196;TISSUE SPECIFICITY
      tissue: Brown adipose tissue.
    7. 7.
      "A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus."
      Mori H. , Okazawa H. , Iwamoto K. , Maeda E. , Hashiramoto M. , Kasuga M.
      Diabetologia44:373-376(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-229
    8. 8.
      "Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio."
      Herrmann S.M. , Wang J.G. , Staessen J.A. , Kertmen E. , Schmidt-Petersen K. , Zidek W. , Paul M. , Brand E.
      J. Mol. Med.81:327-332(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-64
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